Eduardo Magalhães Rego
Professor of Hematology/Oncology, Medical School of Ribeirão Preto, University of São Paulo
1983-1988 Doctor of Medicine (M.D.) Medical School of Ribeirão Preto of the University of São Paulo
|Research Interests|| |
Hematological malignancies, in particular acute leukemias
|Research Overview|| |
The main focus of our group is to integrate basic and clinical research on acute leukemias, in special acute myeloid leukemias. In order to have a better insight on the molecular basis of leukemogenesis, we have been studying acute promyelocytic leukemia (APL) as a model. We have been addressing the following questions:
1. Which cell subpopulation acts the leukemia initiating cells and how is quiescence and energy generation regulated in this subset;
2. Which microRNAs act as key regulators of differentiation in APL blasts and whether their expression profile are associated with treatment outcome;
3. Does the expression of transcriptinally active and inactive isoforms of the p73 gene affect the response to ATRA and if so how?
4. What is the role of microparticles and annexin II expression in APL-associated coagulopathy;
5. Can the molecular monitoring of the PML/RARA fusion gene using RQ-PCR technology predict relapse better than the routinely used RT-PCR method?;
6. Is leukemia relapse is associated with additional mutagenic events?
7. In leukemia prone syndromes, such as dyskeratosis congenita, which pathways confer survival advantage to hematopoietic progenitors and are associated in malignant transformation. Finally, our group is coordinating in Brazil the International Consortium on APL, which is a trial aiming to improve the treatment outcome of APL patients in developing countries.
|Lab Staff|| |
1. PhD students:
Molecular Biology Technicians
Andréia M Leopoldino, PhD
|International Collaborators|| |
Dr Davide Rugero,
Prof. Ellen Solomon,
Prof. Hau C.Kwaan,
Prof. Stefan Bohlander,
|Facilities Coordination|| |
Flow Cytometry and Sorting Facility,
|Selected Publications|| |
1. Dos Santos GA, Abreu E Lima RS, Pestana CR, Lima AS, Scheucher PS, Thomé CH, Gimenes-Teixeira HL, Santana-Lemos BA, Lucena-Araujo AR, Rodrigues FP, Nasr R,Uyemura SA, Falcão RP, de Thé H, Pandolfi PP, Curti C, Rego EM. (+)α-Tocopheryl succinate inhibits the mitochondrial respiratory chain complex I and is as effective as arsenic trioxide or ATRA against acute promyelocytic leukemia in vivo. Leukemia. 2011. doi: 10.1038/leu.2011.216.