Júlio César Voltarelli

Full Professor of Clinical Medicine, Division of Clinical Immunology, Medical School of Ribeirão Preto, University of São Paulo, Brazil.
In memorian

jcvoltar@fmrp.usp.br

PubMed Scopus Scielo ResearchID 

Education  

1967-1972 Graduated in Medicine, Medical School of Ribeirão Preto, University of São Paulo, Brazil
1973-1974 Residence in Clinical Medicine and Hematology, Medical School of Ribeirão Preto, University of São Paulo, Brazil
1975-1978 Masters in Clinical Medicine, Medical School of Ribeirão Preto, University of São Paulo, Brazil
1978-1981 PhD in Clinical Medicine, Medical School of Ribeirão Preto, University of São Paulo, Brazil of Ribeirão Preto, University of São Paulo, Brazil
1985-1986 Postdoctoral Research Fellow, University of California, San Francisco, USA
1987-1988 Postdoctoral Research Fellow, Fred Hutchinson Cancer Research Center, Seattle, USA
1989 Full Professor, University of São Paulo, Brazil
1999-2000 Postdoctoral Research Fellow, Scripps Research Institute, San Diego, California, USA

Research Interests  

Bone Marrow Transplantation
Autoimmune Diseases
Cell therapy
Immunogenetics
Applied Immunology

Research Overview  

The major goal of our group is to evaluate the therapeutic potential of stem cell transplantation in patients with autoimmune diseases and to understand the immune mechanisms involved in those therapies. The group has experience with basic and applied immunology, experimental animal models of autoimmune diseases, transplantation and cell therapy. The research lines include: a, Treatment of autoimmune diseases with autologous hematopoietic stem cell transplantation: evaluation of therapeutic response and mechanisms of action; Treatment of experimental models of autoimmune diseases with mesenchymal stem cell infusions: evaluation of therapeutic response and mechanisms of action; Treatment of extensive burn wounds with mesenchymal stem cells:  evaluation of therapeutic response and mechanisms of action; Analysis of functional characteristics and genetic profiling of stem cells isolated from patients with autoimmune diseases.

Lab Staff  

Bone Marrow Transplantation Group
Belinda P. Simoes Medical Doctor, PhD
Maria C. B. Oliveira Medical Doctor, PhD
Ana B. P. L. Stracieri Medical Doctor, PhD
Daniela A. Moraes Medical Doctor, PhD
Fabiano Pieroni Medical Doctor, PhD
George M. N. Barros Medical Doctor, PhD
Carlos E. B. Couri Medical Doctor, PhD

Basic and Applied Immunology Group
Kelen Cristina Ribeiro Malmegrim Researcher, PhD
Carolina Caliári Oliveira, PhD Student
Mariana Rodrigues Davanso, Master Student
Júlia Teixeira Cottas de Azevedo, Master Student
Kalil Alves de Lima, Master Student
Lucas Coelho Marliére Arruda, PhD Student
Rosane Falasco Bolzoni, Technician
Ana Júlia Bandeira Machry, Technician

Collaborators  

Eduardo Donadi, MD, PhD
Faculdade de Medicina de Ribeirão Preto, USP
Departamento de Clínica Médica
Laboratório de Imunogenética
eadonadi@fmrp.usp.br

João Santana da Silva, PhD
Faculdade de Medicina de Ribeirão Preto, USP
Departamento de Bioquímica e Imunologia
Laboratório de Imunoparasitologia
jsdsilva@fmrp.usp.br

Milton César Foss, PhD
Faculdade de Medicina de Ribeirão Preto, USP
Departamento de Clínica Médica
Laboratório de Endocrinologia
mcfoss@fmrp.usp.br

Ângela Leal, MD, PhD
Universidade Federal de São Carlos
Departamento de Medicina
Laboratório de Endocrinologia
angelaleal@ufscar.br

International Collaborators  

Richard K. Burt, MD, PhD
Associate Professor in Medicine-Immunotherapy for Autoimmune Diseases
Northwestern University Feinberg School of Medicine
Division of Immunotherapy
Chicago, IL 60611, USA
rburt@northwestern.edu

Dominique Farge, MD, PhD
Professor of Internal Medicine
Unité de Médecine Interne et Pathologie Vasculaire
Inserm U976, Hopital Saint-Louis, AP-HP, Paris-7 Université Denis Diderot
1 avenue Claude Vellefaux, 75010 Paris
Dominique.farge-bancel@sls.aphp.fr

Bart Otto Roep, MD, PhD
Professor of Medicine (Diabetology & Immunopathology)
Leiden University Medical Center
Department Immunohematology & Blood Transfusion, E3-Q
Albinusdreef 2
2333 ZA Leiden, The Netherlands
B.O.Roep@lumc.nl

Facilities Coordination  

HLA Genotyping Laboratory (Blood Center of Ribeirão Preto, School of Medicine of Ribeirão Preto, University of São Paulo, Brazil)

Bone Marrow Transplantation Unit (University Hospital, School of Medicine of Ribeirão Preto, University of São Paulo, Brazil)

Selected Publications  

1. Couri CE, Voltarelli JC.Stem cell-based therapies and immunomodulatory approaches in newly diagnosed type 1 diabetes. Curr Stem Cell Res Ther. 2011 Mar 1; 6(1):10-5.
2. Godoi DF, Cardoso CR, Ferraz DB, Provinciatto PR, Cunha FQ, Silva JS, Voltarelli JC. Hematopoietic SCT modulates gut inflammation in experimental inflammatory bowel disease. Bone Marrow Transplant. 2010 Oct; 45(10):1562-71.
3. Couri CE, Oliveira MC, Stracieri AB, Moraes DA, Pieroni F, Barros GM, Madeira MI, Malmegrim KC, Foss-Freitas MC, Simões BP, Martinez EZ, Foss MC, Burt RK, Voltarelli JC. C-peptide levels and insulin independence following autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus. JAMA. 2009, 301(15):1573-9.
4. Autologous non-myeloablative haemopoietic stem cell transplantation in relapsing-remitting multiple sclerosis: a phase I/II study. Burt RK, Loh Y, Cohen B, Stefoski D, Balabanov R, Katsamakis G, Oyama Y, Russell EJ, Stern J, Muraro P, Rose J, Testori A, Bucha J, Jovanovic B, Milanetti F, Storek J, Voltarelli JC, Burns WH. Lancet Neurol. 2009 Mar; 8(3):244-53.
5. Voltarelli JC, Couri CE, Stracieri AB, Oliveira MC, Moraes DA, Pieroni F, Barros GM, Madeira MI, Malmegrim KC, Foss-Freitas MC, Simões BP, Foss MC, Squiers E, Burt RK. Autologous hematopoietic stem cell transplantation for type 1 diabetes. Ann. N. Y. Acad Sci. 2008 Dec; 1150:220-9.
6. Voltarelli JC, Couri CEB, Oliveira MCB, Stracieri ABPL, Moraes DA, Godoi DF, Coutinho MA, Malmegrim KCR, Foss-Freitas MC, Foss MC, Simões BP, Squiers EC, Burt RK.Autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus. JAMA. 2007; 297:1568-1576.
7. Pieroni F, Stracieri AB, Moraes DA, Paton EJ, Saggioro FP, Barros GM, Barros JC, Oliveira MC, Coutinho MA, Castro NS, Vigoritto AC, Trabasso P, Souza CA, de Souza MP, Mauad MA, Colturato VA, Simões BP, Foss NP, Voltarelli JC. Six cases of leprosy associated with allogeneic hematopoietic SCT. Bone Marrow Transplant. 2007; 40(9):859-63.
8. Burt RK, Marmont A, Oyama Y, Slavin S, Arnold R, Hiepe F, Fassas A, Snowden J, Schuening F, Myint H, Patel DD, Collier D, Heslop H, Krance R, Statkute L, Verda L, Traynor A, Kozak T, Hintzen RQ, Rose JW, Voltarelli J, Loh Y, Territo M, Cohen BA, Craig RM, Varga J, Barr WG. Randomized controlled trials of autologous hematopoietic stem cell transplantation for autoimmune diseases: the evolution from myeloablative to lymphoablative transplant regimens. Arthritis Rheum. 2006; 54(12):3750-60.
9. Couri CEB, Foss MC, Voltarelli JC. Secondary prevention of type I diabetes mellitus: stopping immune destruction and promoting B-cell regeneration. Braz J Med Biol Res. 2006; 39:1271-1280.
10. Burt RK, Cohen B, Rose J, Petersen F, Oyama Y, Stefoski D, Katsamakis G, Carrier E, Kozak T, Muraro PM, Martin R, Hintzen R, Slavin S, Karussis D, Haggiag S, Voltarelli JC, Ellison GW, Jovanovic B, Popat U, McGuirk J, Statkute L, Verda L, Haas J, Arnold R. Hematopoietic stem cell transplantation for multiple sclerosis. Arch Neurol 2005; 62: 860-864.
11. Voltarelli JC, Oliveira MCB, Stracieri ABPL, Godoi DF, Moraes DA, Coutinho MA, Malmegrim KCR, Santos AC. Hematopoietic stem cell transplantation for refractory Takayasu’s arteritis. Rheumatology 2004; 43:1308-1309.
12. Voltarelli JC, Ouyang J. Hematopoietic stem cell transplantation for autoimmune diseases in developing countries: current status and future prospectives. Bone Marrow Transplant. 2003; 32: S69-S71.