Roberto Passetto Falcão, MD/PhD

Full Professor of Medicine, FMRP/USP
Member of Editorial Board:  Journal of the Brazilian Medical Association, Hospital Israelita Albert Einstein, Brazilian Journal of Hematology and Hemotherapy

rpfalcao@fmrp.usp.br
PubMed Scopus

Education  

1961-1966 MD degree, University of São Paulo at Ribeirão Preto Medical School (FMRP/USP), Ribeirão Preto, SP, Brazil
1967-1968 Residency in Internal Medicine, University Hospital, FMRP/USP Clinical Fellowship in Hematology, University Hospital, FMRP/USP
1972 PhD in Medical Sciences, FMRP/USP 
1975-1976 Postdoctoral Fellowship, Nuffield department of Clinical Medicine, Oxford University, UK
1980 Full Professor, University of São Paulo, Brazil

Research Interests  

Hematology
Bone marrow failure
Lymphoproliferative diseases 

Research Overview  

Our laboratory is interested in the study of lymphoproliferative diseases and in acute leukemias. 

Lab Staff  

Aglair Bergamo Garcia, Lab manager
Denise Aparecida Palma, Lab manager
Felipe Magalhães Furtado, PhD student
Fernanda Borges ribeiro, PhD student
Fabio Morato de Oliveira, FAPESP Investigator

Collaborators    
International Collaborators    
Facilities Coordination    
Selected Publications  

1-Halofuginone has anti-proliferative effects in acute promyelocytic leukemia by modulating the transforming growth factor beta signaling pathway.de Figueiredo-Pontes LL, Assis PA, Santana-Lemos BA, Jácomo RH, Lima AS, Garcia AB, Thomé CH, Araújo AG, Panepucci RA, Zago MA, Nagler A, Falcão RP, Rego EM. PLoS One. 2011;6(10):e26713. Epub 2011 Oct 28.
2-(+)α-Tocopheryl succinate inhibits the mitochondrial respiratory chain complex I and is as effective as arsenic trioxide or ATRA against acute promyelocytic leukemia in vivo. Dos Santos GA, Abreu E Lima RS, Pestana CR, Lima AS, Scheucher PS, Thomé CH, Gimenes-Teixeira HL, Santana-Lemos BA, Lucena-Araujo AR, Rodrigues FP, Nasr R, Uyemura SA, Falcão RP, de Thé H, Pandolfi PP, Curti C, Rego EM. Leukemia. 2011 Aug 26. doi: 10.1038/leu.2011.216.
3-Monoclonal B-cell lymphocytosis: a brief review for general clinicians. Matos DM, Falcão RP. Sao Paulo Med J. 2011 May;129(3):171-5.
4-Antibody-targeted horseradish peroxidase associated with indole-3-acetic acid induces apoptosis in vitro in hematological malignancies. Dalmazzo LF, Santana-Lemos BA, Jácomo RH, Garcia AB, Rego EM, da Fonseca LM, Falcão RP. Leuk Res. 2011 May;35(5):657-62.
5-High expression of AURKA and AURKB is associated with unfavorable cytogenetic abnormalities and high white blood cell count in patients with acute myeloid leukemia. Lucena-Araujo AR, de Oliveira FM, Leite-Cueva SD, dos Santos GA, Falcao RP, Rego EM. Leuk Res. 2011 Feb;35(2):260-4.
6-Incidence and risk factors of aplastic anemia in Latin American countries: the LATIN case-control study. Maluf E, Hamerschlak N, Cavalcanti AB, Júnior AA, Eluf-Neto J, Falcão RP, Lorand-Metze IG, Goldenberg D, Santana CL, Rodrigues Dde O, Passos LN, Rosenfeld LG, Pitta M, Loggetto S, Ribeiro AA, Velloso ED, Kondo AT, Coelho EO, Pintão MC, de Souza HM, Borbolla JR, Pasquini R. Haematologica. 2009 Sep;94(9):1220-6.
7-Monoclonal B-cell lymphocytosis in first-degree relatives of patients with sporadic (non-familial) chronic lymphocytic leukaemia. Matos DM, Ismael SJ, Scrideli CA, de Oliveira FM, Rego EM, Falcão RP. Br J Haematol. 2009 Nov;147(3):339-46..
8-Constitutional hypomorphic telomerase mutations in patients with acute myeloid leukemia. Calado RT, Regal JA, Hills M, Yewdell WT, Dalmazzo LF, Zago MA, Lansdorp PM, Hogge D, Chanock SJ, Estey EH, Falcão RP, Young NS. Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1187-92.
9-The presence of CD56/CD16 in T-cell acute lymphoblastic leukaemia correlates with the expression of cytotoxic molecules and is associated with worse response to treatment. Dalmazzo LF, Jácomo RH, Marinato AF, Figueiredo-Pontes LL, Cunha RL, Garcia AB, Rego EM, Falcão RP. Br J Haematol. 2009 Jan;144(2):223-9.
10-Incidence and risk factors for agranulocytosis in Latin American countries–the Latin Study: a multicenter study. Hamerschlak N, Maluf E, Biasi Cavalcanti A, Avezum Júnior A, Eluf-Neto J, Passeto Falcão R, Lorand-Metze IG, Goldenberg D, Leite Santana C, de Oliveira Werneck Rodrigues D, Nascimento da Motta Passos L, Oliveira de Miranda Coelho E, Tostes Pintão MC, Moraes de Souza H, Borbolla JR, Pasquini R. Eur J Clin Pharmacol. 2008 Sep;64(9):921-9.
11-SAGE analysis demonstrates increased expression of TOSO contributing to Fas-mediated resistance in CLL. Proto-Siqueira R, Panepucci RA, Careta FP, Lee A, Clear A, Morris K, Owen C, Rizzatti EG, Silva WA Jr, Falcão RP, Zago MA, Gribben JG. Blood. 2008 Jul 15;112(2):394-7.
12-Determination of P-glycoprotein, MDR-related protein 1, breast cancer resistance protein, and lung-resistance protein expression in leukemic stem cells of acute myeloid leukemia. de Figueiredo-Pontes LL, Pintão MC, Oliveira LC, Dalmazzo LF, Jácomo RH, Garcia AB, Falcão RP, Rego EM. Cytometry B Clin Cytom. 2008
13-miRNA expression profiles in chronic lymphocytic and acute lymphocytic leukemia. Zanette DL, Rivadavia F, Molfetta GA, Barbuzano FG, Proto-Siqueira R, Silva-Jr WA, Falcão RP, Zago MA. Braz J Med Biol Res. 2007
14-Mitochondrial DNA sequence variation in single cells from leukemia patients. Yao YG, Ogasawara Y, Kajigaya S, Molldrem JJ, Falcão RP, Pintão MC, McCoy JP Jr, Rizzatti EG, Young NS. Blood. 2007 Jan 15;109(2):756-62
15-Gene expression profiling of mantle cell lymphoma cells reveals aberrant expression of genes from the PI3K-AKT, WNT and TGFbeta signalling pathways. Rizzatti EG, Falcão RP, Panepucci RA, Proto-Siqueira R, Anselmo-Lima WT, Okamoto OK, Zago MA. Br J Haematol. 2005 Aug;130(4):516-26.