Kelen C. R. M. Farias
Researcher, Division of Clinical Immunology, Medical School of Ribeirão Preto, University of São Paulo, Brazil.
kelen@hemocentro. fmrp.usp.br
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Education  

1993-1997 BSc. Pharmacy-Biochemistry, University of the State of São Paulo (UNESP),Brazil
2002-2006 Doctorate (Immunology), Medical School of Ribeirão Preto, University of São Paulo, Brazil
2006-2009 Post-Doctorate (Immunology), Medical School of Ribeirão Preto, University of São Paulo, Brazil
2009-actual Researcher position, Medical School of Ribeirão Preto, University of São Paulo, Brazil of Ribeirão Preto, University of São Paulo, Brazil 

Research Interests  

Autoimmune diseases
Bone marrow Transplantation
Stem cell therapy
Immunoregulation
Gene expression 

Research Overview   The major goal of our group is to evaluate the therapeutic potential of stem cell transplantation in patients with autoimmune diseases and to understand the immune mechanisms involved in those therapies. The group has experience with basic and applied immunology, experimental animal models of autoimmune diseases, transplantation and cell therapy. The research lines include: a, Treatment of autoimmune diseases with autologous hematopoietic stem cell transplantation: evaluation of therapeutic response and mechanisms of action; Treatment of experimental models of autoimmune diseases with mesenchymal stem cell infusions: evaluation of therapeutic response and mechanisms of action; Treatment of extensive burn wounds with mesenchymal stem cells:  evaluation of therapeutic response and mechanisms of action; Analysis of functional characteristics and genetic profiling of stem cells isolated from patients with autoimmune diseases. 
Lab Staff  

Basic and Applied Immunology Group
Juliana Navarro Ueda Yaochite, PhD Student
Carolina Caliári Oliveira, PhD Student
Gislane Lelis Vilela de Oliveira, PhD Student
Mariana Rodrigues Davanso, Master Student
Júlia Teixeira Cottas de Azevedo, Master Student
Kalil Alves de Lima, Master Student
Lucas Coelho Marliére Arruda, Master Student
Rosane Falasco Bolzoni, Technician
Ana Júlia Bandeira Machry, Technician

Collaborators  

João Santana da Silva, PhD
Faculdade de Medicina de Ribeirão Preto, USP
Departamento de Bioquímica e Imunologia
Laboratório de Imunoparasitologia
jsdsilva@fmrp.usp.br

Cristina Ribeiro de Barros Cardoso, MD, PhD
Faculdade de Ciências Farmacêuticas de Ribeirão Preto, USP
Departamento de Análises Clínicas e Toxicológicas
cristina@fcfrp.usp.br

Fabíola Atié de Castro, PhD
Faculdade de Ciências Farmacêuticas de Ribeirão Preto, USP
Departamento de Análises Clínicas e Toxicológicas
castrofa@fcfrp.usp.br

Ângela Leal, MD, PhD
Universidade Federal de São Carlos
Departamento de Medicina
Laboratório de Endocrinologia
angelaleal@ufscar.br 

International Collaborators  

João Santana da Silva, PhD
Faculdade de Medicina de Ribeirão Preto, USP
Departamento de Bioquímica e Imunologia
Laboratório de Imunoparasitologia
jsdsilva@fmrp.usp.br

Cristina Ribeiro de Barros Cardoso, MD, PhD
Faculdade de Ciências Farmacêuticas de Ribeirão Preto, USP
Departamento de Análises Clínicas e Toxicológicas
cristina@fcfrp.usp.br

Fabíola Atié de Castro, PhD
Faculdade de Ciências Farmacêuticas de Ribeirão Preto, USP
Departamento de Análises Clínicas e Toxicológicas
castrofa@fcfrp.usp.br

Ângela Leal, MD, PhD
Universidade Federal de São Carlos
Departamento de Medicina
Laboratório de Endocrinologia
angelaleal@ufscar.br 

Facilities Coordination    
Selected Publications  

1. Saldanha-Araujo F, Haddad R, Malmegrim de Farias KC, Alves Souza AD, Palma PV, Araujo AG, Orellana MD, Voltarelli JC, Covas DT, Zago MA, Panepucci RA. Mesenchymal stem cells promote the sustained expression of CD69 on activated T-lymphocytes: roles of canonical and non-canonical NF-κB signaling. J Cell Mol Med. 2011 Jul 21. doi: 10.1111/j.1582-4934.2011.01391.x. [Epub ahead of print]
2. Couri CE, Oliveira MCB, Stracieri AB, Moraes DA, Pieroni F, Barros GM, Madeira MI, Malmegrim KC, Foss-Freitas MC, Simões BP, Martinez EZ, Foss MC, Burt RK, Voltarelli JC. C-peptide levels and insulin independence following autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus. JAMA. 2009; 301(15):1573-9.
3.Voltarelli JC, Couri CE, Stracieri AB, Oliveira MC, Moraes DA, Pieroni F, Barros GM, Madeira MI, Malmegrim KC, Foss-Freitas MC, Simões BP, Foss MC, Squiers E, Burt RK. Autologous hematopoietic stem cell transplantation for type 1 diabetes. Ann. N. Y. Acad Sci. 2008; 1150:220-9.
4.Voltarelli JC, Couri CEB, Stracieri ABPL, Oliveira MC, Moraes DA, Pieroni F, Coutinho MA, Malmegrim KC, Foss-Freitas MC, Foss MC, Simões BP, Squiers EC, Burt RK. Autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus. JAMA; 2007; 297:1568-1576.
5.Schilders G, Raijmakers R, Malmegrim KC, Vande Walle L, Saelens X, Vree Egberts W, van Venrooij WJ, Vandenabeele P, Pruijn GJ. Caspase-mediated cleavage of the exosome subunit PM/Scl-75 during apoptosis. Arthritis Res Ther. 2007; 9(1):R12.
6.Voltarelli JC, Oliveira MCB, Stracieri ABPL, Godoi DF, Moraes DA, Coutinho MA, Malmegrim KC, Santos AC. Haematopoeitic stem cell transplantation for refractory Takayasu´s arteritis. Rheumatology. 2004; 43:1308-1309.
7.Zampieri S, Mahler M, Blüthner M, Qiu Z, Malmegrim KC, Ghirardello A, Doria A, van Venrooij WJ, Raats JMH. Recombinant anti-P protein autoantibodies isolated from a human autoimmune library: reactivity, specificity and epitope recognition. Cell and Molecular Life Sciences. 2003; 60: 588-598.
8.Malmegrim de Farias KCR, Saelens X, Pruijn GJM, Vandenabeele P, van Venrooij WJ. Caspase-mediated cleavage of the UsnRNP associated Sm-F protein during apoptosis. Cell Death and Differentiation. 2003; 10: 570-579.