Fabiana F. Bressan
M.V. Msc. FZEA/USP
fabianabressan@usp.br
View a complete PubMed search
Education 2001-2005 Graduated in Veterinary Medicine and Animal Sciences, University of São Paulo, Brazil
2006-2008 Master Thesis in Veterinary Medicine (Animal Reproduction), School of Veterinary Medicine and Animal Sciences, University of São Paulo
2009-2013 PhD in Science, School of Animal Sciences and Food Engineering, University of São Paulo
Research Interests Cellular reprogramming
Nuclear transfer
Pluripotent stem cells
Biotechnology of reproduction
Research Overview As part of Dr. Flavio Meirelles´ team, we have focused the studies on animal reproduction, especially with the use of cellular and molecular biotechnology, in vitro embryo production, somatic cell nuclear transfer, animal transgenesis and production of embryonic stem cell lineages obtained from farm animals. The mastering in Animal Reproduction enabled the implementation of a bovine transgenic animal (GFP-positive) used for maternal-fetal interactions in cloned offspring. The PhD is focused on the study of nuclear reprogramming through nuclear transfer and direct reprogramming (induced reprogramming or iPS cells). Moreover, ongoing researches involves the production of farm animal bioreactors, dissection of molecular pathways involved in pluripotency and clinical therapy using mesenchymal stem cells in animals.
Lab Staff  
Collaborators
International Collaborators
Facilities Coordination
Selected Publications 1. MARTINS, S. M. M. K. ; ANDRADE, A. F. C. ; ARRUDA, R. P. ; ZAFFALON, F. G. ; Bressan, F. F. ; PUGINI, S. ; CHIARATTI, M. R. ; MELO, M. P. ; TOBIAS, C. ; MORETTI, A. . Organic selenium supplementation increases PHGPx but does not improve viability in chilled boar semen. Andrologia (Berlin) , v. x, p. n/a-n/a, 2014.

2. ROSSETO, A. C. ; BRUNO, D. G. ; MARTINS, S. M. M. K. ; LAGO, V. ; PINESE, M. E. ; VIANNA, W. L. ; DAGLI, M. L. Z. ; Bressan, F. F. ; ANDRADE, A. F. C. ; RAVAGNANI, G. M. ; TORRES, M. A. ; MORETTI, A. S. . Exploring the effects of second estrus synchronization and dietary flushing on the incidence of ovarian cysts in gilts by using exogenous gonadotropins. Brazilian Journal of Veterinary Research and Animal Science (Impresso), v. 50, p. 307-315, 2014.

3. Bressan, F. F. ; SANGALLI, J. R. ; PESSOA, L. V. F. ; PIRES, P. R. L. ; MEIRELLES, F. V. . Insights on bovine genetic engineering and cloning. Pesquisa Veterinária Brasileira (Impresso) , v. 33, p. 113, 2014.

4. MARTINS, S. M. M. K. ; ANDRADE, A. F. C. ; ZAFFALON, F. G. ; PARAZZI, L. J. ; Bressan, F. F. ; PUGINI, S. ; MELO, M. P. ; CHIARATTI, M. R. ; MARINO, C. T. ; AFONSO, E. R. ; MORETTI, A. S. ; ARRUDA, R. P. . Organic selenium increases PHGPx, but does not affect quality sperm in raw boar semen. Livestock Science (Print) , v. 164, p. 175-178, 2014.

5. DE BEM, T. H. C. ; ADONA, P. ; Bressan, Fabiana Fernandes ; MESQUITA, Lígia Garcia ; CHIARATTI, M. R. ; MEIRELLES, Flávio Vieira ; LEAL, C. L. V. . The influence of morphology, follicle size and Bcl-2 and Bax transcripts on the developmental competence of bovine oocytes.. Reproduction in Domestic Animals (1990) , v. x, p. x, 2014.

6. Pereira, Flavia Thomaz Verechia ; OLIVEIRA, LILIAN J. ; BARRETO, RODRIGO DA SILVA NUNES ; MESS, ANDREA ; PERECIN, Felipe ; Bressan, Fabiana Fernandes ; Mesquita, Ligia Garcia ; MIGLINO, MARIA ANGELICA ; PIMENTEL, JOSÉ RODRIGOVALIM ; NETO, PAULO FANTINATO ; MEIRELLES, Flávio Vieira . Fetal-Maternal Interactions in the Synepitheliochorial Placenta Using the eGFP Cloned Cattle Model. Plos One , v. 8, p. e64399, 2013.

7. MEIRELLES, Flávio Vieira ; Chiaratti, Marcos R. ; FERREIRA, R. M. ; PROVIDELO, F. ; Bressan, Fabiana Fernandes . Strategies to increase in vitro embryo yield: lessons from cell and molecular research. Animal Reproduction, v. 10, p. 302, 2013.

8. Monzani, P.S. ; Sangalli, J.R. ; De Bem, T.H.C. ; Bressan, F.F. ; FANTINATO-NETO, P. ; PIMENTEL, J.R.V. ; BIRGEL-JUNIOR, E.H. ; FONTES, A.M. ; COVAS, D.T. ; Meirelles, F.V. . Breeding of transgenic cattle for human coagulation factor IX by a combination of lentiviral system and cloning. Genetics and Molecular Research , v. 12, p. 1, 2013.

9. Bressan, F. F. ; MIRANDA, M. S. ; BAJGELMAN, M. C. ; PERECIN, F. ; MESQUITA, L. G. ; FANTINATO-NETO, P. ; MERIGHE, G. F. K. ; STRAUSS, B. E. ; Meirelles, F. V. . Effects of long-term in vitro culturing of transgenic bovine donor fibroblasts on cell viability and in vitro developmental potential after nuclear transfer. In Vitro Cellular & Developmental Biology. Animal (Print) , v. 49, p. 250-259, 2013.

10. MESQUITA F.S. ; FRANCA, M. R. ; PUGLIESI, G. ; SCOLARI, S. C. ; RAMOS, R. ; OLIVEIRA, M. ; PAPA, P. ; Bressan, F. F. ; MEIRELLES, F. V. ; SILVA, L. A. ; NOGUEIRA, G. P. ; BERTAN, Claudia Maria ; BINELLI, Mário . Manipulation of the periovulatory sex-steroidal milieu affects endometrial but not luteal gene expression on early diestrus Nelore cows. Theriogenology , v. x, p. x, 2013.

11. RIBEIRO, LUCAS F. ; BRESSAN, FABIANA ; FURTADO, GILVAN P. ; MEIRELES, FLAVIO ; WARD, RICHARD J. . d-Xylose detection in Escherichia coli by a xylose binding protein-dependent response. Journal of Biotechnology , v. x, p. x, 2013.

12. MIRANDA, M. S. ; Bressan, F. F. ; MERIGHE, G. K. F. ; KING, William Allan ; De Bem, T.H.C. ; OHASHI, O. M. ; MEIRELLES, F. V. . Nuclear Transfer with Apoptotic Bovine Fibroblasts: can programmed cell death be reprogrammed? DOI: 10.1089/cell.2011.0080. Cellular Reprogramming , v. 14, p. 217, 2012.

13. VIEIRA, F. K. ; FORELL, F. ; GERGER, R. P. C. ; AGUIAR, L. H. ; FELTRIN, C. ; CALDERON, C. E. M. ; CARNEIRO, I. S. ; BRESSAN, FF. ; URIO, M. ; COSTA, U. M. ; BERTOLINI, L. R. ;MEIRELLES, F. V. ; BERTOLINI, M. . In Vitro Development and Cell Allocation After the Aggregation of Syngeneic Wild Type and Fluorescence-Expressing Bovine Cloned Embryos. Acta Scientiae Veterinariae (Online) , v. 40, p. 1057, 2012.

14. GONCALVES, N. J. N. ; Bressan, F.F. ; SOUZA, A. ; MARTINS, D. S. ; MIGLINO, M. A. ; MEIRELLES, F. V. ; PERECIN, F. ; AMBROSIO, C. E. . Canine Fibroblasts Expressing Human Transcription Factors: What is in the Route for the Production of Canine Induced Pluripotent Stem Cells. Reproduction in Domestic Animals (1990) , v. 47, p. 84-87, 2012.

15. RUGGERI, R. R. ; Bressan, F.F. ; WATANABE, Y. F. ; MEIRELLES, F. V. ; Bos-Mikich A. . The use of parthenotegenetic and IVF bovine blastocysts as a model for the creation of human embryonic stem cells under defined conditions. Journal of Assisted Reproduction and Genetics , v. 29, p. 1039-1043, 2012.

16. LESSA, THAIS BORGES ; CARVALHO, RAFAEL CARDOSO ; FRANCIOLLI, ANDRÉ LUIS ; DE OLIVEIRA, LILIAN JESUS ; BARRETO, RODRIGO SILVA ; FEDER, DAVID ; Bressan, Fabiana Fernandes ; MIGLINO, Maria Angélica ; AMBRÓSIO, CARLOS EDUARDO . Muscle reorganisation through local injection of stem cells in the diaphragm of mdx mice. Acta Veterinaria Scandinavica (Online) , v. 54, p. 73, 2012.

17. de Andrade, André Furugen Cesar ; Bressan, Fabiana Fernandes ; Celeghini, Eneiva Carla Carvalho ; Martins, Simone Maria Massami Kitamura ; Zaffalon, Fabiane Gilli ; Nascimento, Juliana ; de Arruda, Rubens Paes . Post-thaw addition of seminal plasma reduces tyrosine phosphorylation on the surface of cryopreserved equine sperm, but does not reduce lipid peroxidation. Theriogenology , v. 77, p. 1866-1872.e3, 2012.

18. LATORRE, ANDREIA O. ; CANICEIRO, BEATRIZ D. ; FUKUMASU, HEIDGE ; GARDNER, DALE R. ; LOPES, FABRICIO M. ; WYSOCHI, HARRY L. ; DA SILVA, TEREZA C. ; HARAGUCHI, MITSUE ; Bressan, Fabiana F. ; GÓRNIAK, SILVANA L. . Ptaquiloside reduces NK cell activities by enhancing metallothionein expression, which is prevented by selenium. Toxicology (Amsterdam) , v. 304, p. 100-108, 2012.

19. Forero-Gonzalez, R. A. ; Celeghini, E. C. C. ; RAPHAEL, C. F. ; ANDRADE, A. F. C. ; Bressan, F. F. ; ARRUDA, R. P. . Effects of bovine sperm cryopreservation using different freezing techniques and cryoprotective agents on plasma, acrosomal and mitochondrial membranes. Andrologia (Berlin) , v. 44, p. 154-159, 2012.

20. Monzani, P.S. ; Bressan, F.F. ; Mesquita, L.G. ; Sangalli, J.R. ; Meirelles, F.V. . ?-casein gene expression by in vitro cultured bovine mammary epithelial cells derived from developing mammary glands. Genetics and Molecular Research , v. 10, p. 604-614, 2011.

21. YOKOMIZO, V. M. F. ; BENEMOND, T. M. H. ; Bressan, F. F. ; PIEIRI, N. C. G. ; SANGALLI, J. R. ; CASALS, J. B. ; MARTINS, D. S. ; MEIRELLES, Flávio Vieira . Células-tronco derivadas de tecido adiposo: isolamento, cultivo in vitro e perspectivas de utilização em dermatologia. Surgical & Cosmetic Dermatology, v. 3, p. 55-59, 2011.

22. CASALS, J. B. ; PIEIRI, N. C. G. ; ERCOLIN, A. C. M. ; ROBALLO, K. C. S. ; BARRETO, R. S. N. ; BRESSAN, FF. ; MARTINS, D. S. ; MIGLINO, Maria Angélica ; AMBROSIO, C. E. . The Use of Animal Models for Stroke Research. Comparative Medicine (Memphis) , v. 61, p. 305-313, 2011.

23. Bressan, Fabiana Fernandes ; dos Santos Miranda, Moyses ; PERECIN, Felipe ; De Bem, Tiago Henrique ; Pereira, Flavia Thomaz Verechia ; Russo-Carbolante, Elisa Maria ; Alves, Daiani ; STRAUSS, Bryan ; BAJGELMAN, Marcio ; KRIEGER, José Eduardo ; Binelli, Mario ; Meirelles, Flavio Vieira . Improved Production of Genetically Modified Fetuses with Homogeneous Transgene Expression After Transgene Integration Site Analysis and Recloning in Cattle. Cellular Reprogramming , v. 13, p. 29-36, 2011.

24. Bressan, F.F. ; PERECIN, F. ; SANGALLI, J. R. ; MEIRELLES, F. V. . Reprogramming somatic cells:pluripotency trough gene induction and nuclear transfer. Acta Scientiae Veterinariae (Online) , v. 39, p. s83-s95, 2011.

25. Barreto, R.S.N. ; Miglino, M.A. ; AMBRÃ SIO, C.E. ; PERECIN, F. ; Pereira, F.T.V. ; Oliveira, L.J. ; Meirelles, F.V. ; Bressan, F.F. . Gene expression in placentation of farm animals: An overview of gene function during development. Theriogenology , v. 76, p. 589-597, 2011.

26. de Bem, THC ; BRESSAN, FF. ; CHIARATTI, M. R. ; Rochetti, RC ; SANGALLI, J. ; MIRANDA, MS ; Pires, PRL ; SCHWARZ, Katia Regina Lancelotti ; RV Sampaio ; PERECIN, Felipe ; SMITH, L. C. ; MEIRELLES, F. V. ; ADONA, P. R. ; LEAL, C. L. V. . Viable Calves Produced by Somatic Cell Nuclear Transfer Using Meiotic-Blocked Oocytes. Cellular Reprogramming , p. 110721084832009, 2011.

27. CHIARATTI, M. R. ; Bressan, F. F. ; FERREIRA, C. R. ; CAETANO, A. R. ; SMITH, L. C. ; VERCESI, A. E. ; Meirelles, F. V. . Embryo Mitochondrial DNA Depletion Is Reversed During Early Embryogenesis in Cattle. Biology of Reproduction , v. 82, p. 76-85, 2009.

28. BRESSAN, FF. ; DE BEM, Tiago Henrique Câmara ; PERECIN, Felipe ; PERECIN, Felipe ; LOPES, Flávia Lombardi ; AMBROSIO, Carlos Eduardo ; MEIRELLES, Flávio Vieira ; MIGLINO, Maria Angélica . Unearthing the roles of imprinted genes in the placenta. Placenta (Eastbourne) , v. 30, p. 823-834, 2009.

29. MIRANDA, Moysés dos Santos ; BRESSAN, FF. ; ZECCHIN, Karina Gottardello ; VERCESI, Anibal Eugênio ; MESQUITA, Lígia Garcia ; MERIGHE, Giovana Krempel Fonseca ; KING, William Allan ; OHASHI, Otávio Mitio ; PIMENTEL, José Rodrigo Valim ; PERECIN, Felipe ; PERECIN, Felipe ; MEIRELLES, Flávio Vieira . Serum-Starved Apoptotic Fibroblasts Reduce Blastocyst Production but Enable Development to Term after SCNT in Cattle. Cloning and Stem Cells , v. 11, p. 565-573, 2009.

30. BRESSAN, FF. ; MIRANDA, M. S. ; de Bem, TH ; PEREIRA, F. T. V. ; BINELLI, Mário ; MEIRELLES, F. V. . Produção de animais transgênicos por transferência nuclear como modelo de estudo biológico. Revista Brasileira de Reprodução Animal (Impresso), v. 32, p. 240-250, 2008.