Rodrigo T. Calado, MD/PhD
Assistant Professor of Medicine, FMRP/USP
rtcalado@fmrp.usp.br
View a complete PubMed search
Education  

1992-1997 MD degree, University of São Paulo at Ribeirão Preto Medical School (FMRP/USP), Ribeirão Preto, SP, Brazil
1998-2000 Residency in Internal Medicine, University Hospital, FMRP/USP
2000-2001 Clinical Fellowship in Hematology, University Hospital, FMRP/USP
2001-2003 PhD in Medical Sciences, FMRP/USP
2003-2007 Postdoctoral Fellowship, Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health (NHLBI/NIH), Bethesda, MD, USA

Research Interests   Hematology
Bone marrow failure
Telomere diseases
Hematopoietic stem cell biology
Research Overview   Our laboratory is interested in the study of human telomere diseases. We are trying to understand the molecular and cellular mechanisms through which short and dysfunctional telomeres lead to adult stem cell failure, fibrotic diseases, and cancer. For this purpose, we use telomerase-deficient murine models and induced pluripotent stem (iPS) cells to model disease and to identify abnormal pathways derived from deficient telomere repair. We also screen patient samples for telomere length and mutations in novel genes that may be associated with telomere biology.
Lab Staff  

Barbara Amélia Santana Lemos, técnica em laboratório da USP
Raquel de Melo Alves Paiva, pós-doutoranda da USP com bolsa FAPESP
Diego Villa Clé, aluno de doutorado
Pedro Padilha, aluno de doutorado
Leonardo Zanelatto, aluno de doutorado
Flávia Sacilotto Donaires, aluna de doutorado
Natália Scatena, aluna de mestrado
Fernanda Gutierrez Rodrigues, aluna de mestrado
Florencia Tellechea, aluna de mestrado
Juliana Dias, aluna de mestrado
Vinicius Tomazini, aluno de iniciação científica

Collaborators  

Professor Ricardo Pasquini
Federal University of Paraná
Curitiba, PR, Brazil

Elvis Valera, MD
Department of Pediatrics
FMRP/USP
Ribeirão Preto, SP, Brazil

International Collaborators  

Neal S. Young, MD, MACP
Chief, Hematology Branch
National Heart, Lung, and Blood Institute
National Institutes of Health
Bethesda, Maryland, USA

Facilities Coordination    
Selected Publications  

1. Calado RT, Cooper JN, Padilla-Nash HM, Sloand EM, Wu CO, Scheinberg P, Ried T, Young NS. Short telomeres result in chromosomal instability in hematopoietic cells and precede malignant evolution in human aplastic anemia. Leukemia. 2011, Epub ahead of print.
2. Calado RT, Brudno J, Mehta P, Kovacs JJ, Wu C, Zago MA, Chanock SJ, Boyer TD, Young NS. Constitutional telomerase mutations are genetic risk factors for cirrhosis. Hepatology. 2011 May;53(5):1600-7.
3. Scheinberg P, Cooper JN, Sloand EM, Wu CO, Calado RT, Young NS. Association of telomere length of peripheral blood leukocytes with hematopoietic relapse, malignant transformation, and survival in severe aplastic anemia. JAMA. 2010 Sep 22;304(12):1358-64.
4. Chiang YJ, Calado RT, Hathcock KS, Lansdorp PM, Young NS, Hodes RJ. Telomere length is inherited with resetting of the telomere set-point. Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10148-53
5. Calado RT, Young NS. Telomere diseases. N Engl J Med. 2009 Dec 10;361(24):2353-65.
6. Calado RT, Regal JA, Kleiner DE, Schrump DS, Peterson NR, Pons V, Chanock SJ, Lansdorp PM, Young NS. A spectrum of severe familial liver disorders associate with telomerase mutations. PLoS One. 2009 Nov 20;4(11):e7926.
7. Calado RT, Yewdell WT, Wilkerson KL, Regal JA, Kajigaya S, Stratakis CA, Young NS. Sex hormones, acting on the TERT gene, increase telomerase activity in human primary hematopoietic cells. Blood. 2009 Sep 10;114(11):2236-43.8.
8. Calado RT, Regal JA, Hills M, Yewdell WT, Dalmazzo LF, Zago MA, Lansdorp PM, Hogge D, Chanock SJ, Estey EH, Falcão RP, Young NS. Constitutional hypomorphic telomerase mutations in patients with acute myeloid leukemia. Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1187-92.
9. Calado RT, Young NS. Telomere maintenance and human bone marrow failure. Blood. 2008 May 1;111(9):4446-55.
10. Yamaguchi H, Calado RT, Ly H, Kajigaya S, Baerlocher GM, Chanock SJ, Lansdorp PM, Young NS. Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia. N Engl J Med. 2005 Apr 7;352(14):1413-24.