CV

Wilson Araújo Silva Junior

		Wilson A Silva Jr Full Professor of Genetics, FMRP/USP Member of the Brazilian Society of Genetics Head of the Department of Genetics at FMRP-USP Coordinator of the Center of Genomic Medicine of the Medical School of Ribeirão Preto, University of São Paulo Coordinator of the Nucleus of Support for Research in Integrated Systemic Biology of FMRP-USP. wilsonjr@usp.br PubMed Scholar ResearcherID Scopus
Education		1986-1989 Graduated in Biologic Sciences, Federal University of Pará, Brazil 1991-1993 Master Thesis in Genetics, Medical School of Ribeirão Preto, University of São Paulo 1993-1999 PhD in Genetics, Medical School of Ribeirão Preto, University of São Paulo 2005 Full Professor, University of São Paulo, Brazil 2006-2008 Postdoctoral Research Fellow, Ludwig Institute for Cancer Researcher at the Memorial Sloan-Kettering Cancer Center, New York/NY
Research Interests		Cancer Genetics Genomics Genetic Diseases RNA regulation
Research Overview		The major focus of our group is to understand the molecular mechanisms involved in genetic diseases and cancer development. We are using whole genomic analysis to identify and characterize genetic program/gene pathways that drive tumorigenic processes, and biomarkers of diagnosis, prognosis and therapeutic orientation. We are also interested in the characterization of biological properties of Cancer Stem Cells (CSCs), which present self-renewal capacity, unlimited proliferative potential, differentiation competence, and are extremely resistant to radio and chemotherapies. For this pourpose, we are applying next generation sequencing in order to profile gene expression, characterize epigenetic alterations, detect chromosomal rearrangements, and single nucleotide variations in coding and regulatory gene regions (RNAseq, ChIP-Seq, DNA methylation, Exome, and Paired-End protocols) in several solid tumors including: head and neck carcinoma, colorectal carcinoma, glioblastoma multiforme and osteosarcoma.
Lab Staff		*Molecular Genetics Group* Júlio Lorenzi, PhD Student Cleidson de Pádua Alves, Post-Doc/CNPq Daniel Onofre Vidal, Post-Doc/FAPESP Dalila Lucíola Zanette, Post-Doc/FAPESP Bioinformatics Group Israel Tojal da Silva, PhD Bioinformatician Daniel Guariz Pinheiro, PhDBioinformatician Jorge Estefano Santana de Souza, PhD Bioinformatician Marcelo Gomes de Paula, Technical support *Molecular Biology Technicians* Adriana Aparecida Marques Cristiane Ayres Ferreira Anemari Dinarde dos Santos, MSc. Greice Andreotti de Molfetta, PhD.
Collaborators		Silvia Regina Caminada de Toledo, PhD Universidade Federal de São Paulo Laboratório de Genética silviatoledo@graacc.org.br Valeria Valente, PhD Faculdade de Ciências Farmacêuticas de Araraquara/UNESP Laboratório de Biologia Celular valenteval@gmail.com Houtan Noushmehr, PhD Faculdade de Medicina de Ribeirão Preto, USP Laboratório de Biologia Integrativa houtana@gmail.com
International Collaborators		Gerhard A Coetzee, PhD Professor of Urology and Preventive Medicine USC/Norris Cancer Center, NOR6411 1441 Eastlake Ave Los Angeles, CA 90089 Gene Yeo, PhD Assistant Professor Department of Cellular and Molecular Medicine UCSD Bioinformatics Graduate Program USSD Stem Cell Initiative 9500 Gilman Drive, CMM-E La Jolla California, 92093-0695
Facilities Coordination		DNA sequencing (ABI 3500 xL Genetic Analyzer)Next Generation Sequencing (Genome Analyzer IIx, Illumina)Bioinformatics Analysis
Selected Publications		1. Garcia DF, Oliveira TG, Molfetta GA, Garcia LV, Ferreira CA, Marques AA, Silva WA Jr. Biochemical and genetic analysis of butyrylcholinesterase (BChE) in a family, due to prolonged neuromuscular blockade after the use of succinylcholine. Genet Mol Biol. 2011 Jan;34(1):40-4 2. Montoro JR, Mamede RC, Neder Serafini L, Saggioro FP, Figueiredo DL, Silva WA Jr, Jungbluth AA, Spagnoli GC, Zago MA. Expression of cancer-testis antigens MAGE-A4 and MAGE-C1 in oral squamous cell carcinoma. Head Neck. 2011 Nov 15. doi: 10.1002/hed.21880. 3. Kannen V, Marini T, Zanette DL, Frajacomo FT, Silva GE, Silva WA Jr, Garcia SB. The melatonin action on stromal stem cells within pericryptal area in colon cancer model under constant light. Biochem Biophys Res Commun. 2011 Feb 25;405(4):593-8. 4. Silva IT, Vêncio RZ, Oliveira TY, Molfetta GA, Silva WA Jr. ProbFAST: Probabilistic functional analysis system tool. BMC Bioinformatics. 2010 Mar 30;11:161. 5. Pinheiro DG, Galante PA, de Souza SJ, Zago MA, Silva WA Jr. A score system for quality evaluation of RNA sequence tags: an improvement for gene expression profiling. BMC Bioinformatics. 2009 Jun 6;10:170. 6. Dos Santos ML, Gimenes KP, Silva WA Jr, Nagai MA. Transcriptome changes induced by docetaxel in human mammary cell lines expressing different levels of ERBB2. Int J Mol Med. 2009 Jun;23(6):733-43. 7. Silva WA Jr, Gnjatic S, Ritter E, Chua R, Cohen T, Hsu M, Jungbluth AA, Altorki NK, Chen YT, Old LJ, Simpson AJ, Caballero OL. PLAC1, a trophoblast-specific cell surface protein, is expressed in a range of human tumors and elicits spontaneous antibody responses. Cancer Immun. 2007 Nov 6;7:18. 8. Zanette DL, Rivadavia F, Molfetta GA, Barbuzano FG, Proto-Siqueira R, Silva-Jr WA, Falcão RP, Zago MA. miRNA expression profiles in chronic lymphocytic and acute lymphocytic leukemia. Braz J Med Biol Res. 2007 Nov;40(11):1435-40. 9. Amaral FC, Torres N, Saggioro F, Neder L, Machado HR, Silva WA Jr, Moreira AC, Castro M. MicroRNAs differentially expressed in ACTH-secreting pituitary tumors. J Clin Endocrinol Metab. 2009 Jan;94(1):320-3.10. Silva WA Jr, Covas DT, Panepucci RA, Proto-Siqueira R, Siufi JL, Zanette DL, Santos AR, Zago MA. The profile of gene expression of human marrow mesenchymal stem cells. Stem Cells. 2003;21(6):661-9.

Rodrigo Tocantins Calado

		Rodrigo T. Calado, MD/PhD Associate Professor of Medicine, FMRP/USP Coordinator, Graduate Program in Oncology, Stem Cells and Cell Therapy of FMRP-USP Coordinator, Laboratory of Hematology and Laboratory of Clinical Analysis of the Medical School of Ribeirão Preto – USP Associate editor of the Brazilian Journal of Hematology and Hemotherapy Sectional editor of the Brazilian Journal of Medical and Biological Research Member of the Committee on Educational Affairs of the American Society of Hematology Member of the Deliberative Council of the Brazilian Association of Hematology, Hemotherapy and Cell Therapy rtcalado@fmrp.usp.br PubMed Scopus ResearcherID
Education		1992-1997 MD degree, University of São Paulo at Ribeirão Preto Medical School (FMRP/USP), Ribeirão Preto, SP, Brazil 1998-2000 Residency in Internal Medicine, University Hospital, FMRP/USP 2000-2001 Clinical Fellowship in Hematology, University Hospital, FMRP/USP 2001-2003 PhD in Medical Sciences, FMRP/USP 2003-2007 Postdoctoral Fellowship, Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health (NHLBI/NIH), Bethesda, MD, USA 2012 Full Professor, University of São Paulo, Brazil
Research Interests		Hematology Bone marrow failure Telomere diseases Hematopoietic stem cell biology
Research Overview		Our laboratory is interested in the study of human telomere diseases. We are trying to understand the molecular and cellular mechanisms through which short and dysfunctional telomeres lead to adult stem cell failure, fibrotic diseases, and cancer. For this purpose, we use telomerase-deficient murine models and induced pluripotent stem (iPS) cells to model disease and to identify abnormal pathways derived from deficient telomere repair. We also screen patient samples for telomere length and mutations in novel genes that may be associated with telomere biology.
Lab Staff		Barbara Amélia Santana Lemos, técnica em laboratório da USP Raquel de Melo Alves Paiva, pós-doutoranda da USP com bolsa FAPESP Diego Villa Clé, aluno de doutorado Pedro Padilha, aluno de doutorado Leonardo Zanelatto, aluno de doutorado Flávia Sacilotto Donaires, aluna de doutorado Natália Scatena, aluna de mestrado Fernanda Gutierrez Rodrigues, aluna de mestrado Florencia Tellechea, aluna de mestrado Juliana Dias, aluna de mestrado Vinicius Tomazini, aluno de iniciação científica
Collaborators		Professor Ricardo Pasquini Federal University of Paraná Curitiba, PR, Brazil Elvis Valera, MD Department of Pediatrics FMRP/USP Ribeirão Preto, SP, Brazil
International Collaborators		Neal S. Young, MD, MACP Chief, Hematology Branch National Heart, Lung, and Blood Institute National Institutes of Health Bethesda, Maryland, USA
Facilities Coordination
Selected Publications		1. Calado RT, Cooper JN, Padilla-Nash HM, Sloand EM, Wu CO, Scheinberg P, Ried T, Young NS. Short telomeres result in chromosomal instability in hematopoietic cells and precede malignant evolution in human aplastic anemia. Leukemia. 2011, Epub ahead of print. 2. Calado RT, Brudno J, Mehta P, Kovacs JJ, Wu C, Zago MA, Chanock SJ, Boyer TD, Young NS. Constitutional telomerase mutations are genetic risk factors for cirrhosis. Hepatology. 2011 May;53(5):1600-7. 3. Scheinberg P, Cooper JN, Sloand EM, Wu CO, Calado RT, Young NS. Association of telomere length of peripheral blood leukocytes with hematopoietic relapse, malignant transformation, and survival in severe aplastic anemia. JAMA. 2010 Sep 22;304(12):1358-64. 4. Chiang YJ, Calado RT, Hathcock KS, Lansdorp PM, Young NS, Hodes RJ. Telomere length is inherited with resetting of the telomere set-point. Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10148-53 5. Calado RT, Young NS. Telomere diseases. N Engl J Med. 2009 Dec 10;361(24):2353-65. 6. Calado RT, Regal JA, Kleiner DE, Schrump DS, Peterson NR, Pons V, Chanock SJ, Lansdorp PM, Young NS. A spectrum of severe familial liver disorders associate with telomerase mutations. PLoS One. 2009 Nov 20;4(11):e7926. 7. Calado RT, Yewdell WT, Wilkerson KL, Regal JA, Kajigaya S, Stratakis CA, Young NS. Sex hormones, acting on the TERT gene, increase telomerase activity in human primary hematopoietic cells. Blood. 2009 Sep 10;114(11):2236-43.8. 8. Calado RT, Regal JA, Hills M, Yewdell WT, Dalmazzo LF, Zago MA, Lansdorp PM, Hogge D, Chanock SJ, Estey EH, Falcão RP, Young NS. Constitutional hypomorphic telomerase mutations in patients with acute myeloid leukemia. Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1187-92. 9. Calado RT, Young NS. Telomere maintenance and human bone marrow failure. Blood. 2008 May 1;111(9):4446-55. 10. Yamaguchi H, Calado RT, Ly H, Kajigaya S, Baerlocher GM, Chanock SJ, Lansdorp PM, Young NS. Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia. N Engl J Med. 2005 Apr 7;352(14):1413-24.

Roberto Passetto Falcão

		Roberto Passetto Falcão, MD/PhD Full Professor of Medicine, FMRP/USP Member of Editorial Board: Journal of the Brazilian Medical Association, Hospital Israelita Albert Einstein, Brazilian Journal of Hematology and Hemotherapy rpfalcao@fmrp.usp.br PubMed Scopus
Education		1961-1966 MD degree, University of São Paulo at Ribeirão Preto Medical School (FMRP/USP), Ribeirão Preto, SP, Brazil 1967-1968 Residency in Internal Medicine, University Hospital, FMRP/USP Clinical Fellowship in Hematology, University Hospital, FMRP/USP 1972 PhD in Medical Sciences, FMRP/USP 1975-1976 Postdoctoral Fellowship, Nuffield department of Clinical Medicine, Oxford University, UK 1980 Full Professor, University of São Paulo, Brazil
Research Interests		Hematology Bone marrow failure Lymphoproliferative diseases
Research Overview		Our laboratory is interested in the study of lymphoproliferative diseases and in acute leukemias.
Lab Staff		Aglair Bergamo Garcia, Lab manager Denise Aparecida Palma, Lab manager Felipe Magalhães Furtado, PhD student Fernanda Borges ribeiro, PhD student Fabio Morato de Oliveira, FAPESP Investigator
Collaborators
International Collaborators
Facilities Coordination
Selected Publications		1-Halofuginone has anti-proliferative effects in acute promyelocytic leukemia by modulating the transforming growth factor beta signaling pathway.de Figueiredo-Pontes LL, Assis PA, Santana-Lemos BA, Jácomo RH, Lima AS, Garcia AB, Thomé CH, Araújo AG, Panepucci RA, Zago MA, Nagler A, Falcão RP, Rego EM. PLoS One. 2011;6(10):e26713. Epub 2011 Oct 28. 2-(+)α-Tocopheryl succinate inhibits the mitochondrial respiratory chain complex I and is as effective as arsenic trioxide or ATRA against acute promyelocytic leukemia in vivo. Dos Santos GA, Abreu E Lima RS, Pestana CR, Lima AS, Scheucher PS, Thomé CH, Gimenes-Teixeira HL, Santana-Lemos BA, Lucena-Araujo AR, Rodrigues FP, Nasr R, Uyemura SA, Falcão RP, de Thé H, Pandolfi PP, Curti C, Rego EM. Leukemia. 2011 Aug 26. doi: 10.1038/leu.2011.216. 3-Monoclonal B-cell lymphocytosis: a brief review for general clinicians. Matos DM, Falcão RP. Sao Paulo Med J. 2011 May;129(3):171-5. 4-Antibody-targeted horseradish peroxidase associated with indole-3-acetic acid induces apoptosis in vitro in hematological malignancies. Dalmazzo LF, Santana-Lemos BA, Jácomo RH, Garcia AB, Rego EM, da Fonseca LM, Falcão RP. Leuk Res. 2011 May;35(5):657-62. 5-High expression of AURKA and AURKB is associated with unfavorable cytogenetic abnormalities and high white blood cell count in patients with acute myeloid leukemia. Lucena-Araujo AR, de Oliveira FM, Leite-Cueva SD, dos Santos GA, Falcao RP, Rego EM. Leuk Res. 2011 Feb;35(2):260-4. 6-Incidence and risk factors of aplastic anemia in Latin American countries: the LATIN case-control study. Maluf E, Hamerschlak N, Cavalcanti AB, Júnior AA, Eluf-Neto J, Falcão RP, Lorand-Metze IG, Goldenberg D, Santana CL, Rodrigues Dde O, Passos LN, Rosenfeld LG, Pitta M, Loggetto S, Ribeiro AA, Velloso ED, Kondo AT, Coelho EO, Pintão MC, de Souza HM, Borbolla JR, Pasquini R. Haematologica. 2009 Sep;94(9):1220-6. 7-Monoclonal B-cell lymphocytosis in first-degree relatives of patients with sporadic (non-familial) chronic lymphocytic leukaemia. Matos DM, Ismael SJ, Scrideli CA, de Oliveira FM, Rego EM, Falcão RP. Br J Haematol. 2009 Nov;147(3):339-46.. 8-Constitutional hypomorphic telomerase mutations in patients with acute myeloid leukemia. Calado RT, Regal JA, Hills M, Yewdell WT, Dalmazzo LF, Zago MA, Lansdorp PM, Hogge D, Chanock SJ, Estey EH, Falcão RP, Young NS. Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1187-92. 9-The presence of CD56/CD16 in T-cell acute lymphoblastic leukaemia correlates with the expression of cytotoxic molecules and is associated with worse response to treatment. Dalmazzo LF, Jácomo RH, Marinato AF, Figueiredo-Pontes LL, Cunha RL, Garcia AB, Rego EM, Falcão RP. Br J Haematol. 2009 Jan;144(2):223-9. 10-Incidence and risk factors for agranulocytosis in Latin American countries–the Latin Study: a multicenter study. Hamerschlak N, Maluf E, Biasi Cavalcanti A, Avezum Júnior A, Eluf-Neto J, Passeto Falcão R, Lorand-Metze IG, Goldenberg D, Leite Santana C, de Oliveira Werneck Rodrigues D, Nascimento da Motta Passos L, Oliveira de Miranda Coelho E, Tostes Pintão MC, Moraes de Souza H, Borbolla JR, Pasquini R. Eur J Clin Pharmacol. 2008 Sep;64(9):921-9. 11-SAGE analysis demonstrates increased expression of TOSO contributing to Fas-mediated resistance in CLL. Proto-Siqueira R, Panepucci RA, Careta FP, Lee A, Clear A, Morris K, Owen C, Rizzatti EG, Silva WA Jr, Falcão RP, Zago MA, Gribben JG. Blood. 2008 Jul 15;112(2):394-7. 12-Determination of P-glycoprotein, MDR-related protein 1, breast cancer resistance protein, and lung-resistance protein expression in leukemic stem cells of acute myeloid leukemia. de Figueiredo-Pontes LL, Pintão MC, Oliveira LC, Dalmazzo LF, Jácomo RH, Garcia AB, Falcão RP, Rego EM. Cytometry B Clin Cytom. 2008 13-miRNA expression profiles in chronic lymphocytic and acute lymphocytic leukemia. Zanette DL, Rivadavia F, Molfetta GA, Barbuzano FG, Proto-Siqueira R, Silva-Jr WA, Falcão RP, Zago MA. Braz J Med Biol Res. 2007 14-Mitochondrial DNA sequence variation in single cells from leukemia patients. Yao YG, Ogasawara Y, Kajigaya S, Molldrem JJ, Falcão RP, Pintão MC, McCoy JP Jr, Rizzatti EG, Young NS. Blood. 2007 Jan 15;109(2):756-62 15-Gene expression profiling of mantle cell lymphoma cells reveals aberrant expression of genes from the PI3K-AKT, WNT and TGFbeta signalling pathways. Rizzatti EG, Falcão RP, Panepucci RA, Proto-Siqueira R, Anselmo-Lima WT, Okamoto OK, Zago MA. Br J Haematol. 2005 Aug;130(4):516-26.

Marco Antonio Zago

		Marco A. Zago Full Professor of Hematology, FMRP/USP Member of the Brazilian Academy of Sciences Dean of the University of São Paulo Former President of CNPq (National Council for Scientific and Technological Development) Former President and scientific director of the Regional Blood Center of Ribeirão Preto Clinical director of the University Hospital of Medical School of Ribeirão Preto marazago@usp.br PubMed ResearcherID Scholar Scopus View the complete Lattes Curriculum Vitae
Education		1965-1970 Graduated in Medicine, Medical School of Ribeirão Preto, University of São Paulo, FMRP-USP, Brazil. 1971-1973 Master in Clinical Medicine, Medical School of Ribeirão Preto, University of São Paulo, FMRP-USP, Brazil. 1973-1975 PhD in Clinical Medicine, Medical School of Ribeirão Preto, University of São Paulo, FMRP-USP, Brazil. 1976-1977 Postdoctoral Research Fellow, Oxford University 1981 Full Professor, Medical School of Ribeirão Preto, University of São Paulo, FMRP-USP, Brazil
Research Interests		Somatic and Pluripotent Stem Cells Cancer and Leukemia Functional Genomics microRNA and Transcription Factors
Research Overview		In the last few years, we have addressed the characterization of somatic stem cells, including Mesenchymal Stem Cells (MSC) and Hematopoietic Stem Cells (HSC) from different sources, to study the molecular basis of their specific biological characteristics, as well as to provide evidence for their distribution and in vivo role. In fact, we have helped to establish the concept that MSCs occupy a perivascular niche throughout the body, closely resembling pericytes, providing a cell repository for tissue repair and also playing important roles in the maintenance of peripheral immunehomeostasis. In that sense, we provided evidence of a new immunomodulatory mechanism exerted by MSC in response to inflammatory stimuli derived from activated T lymphocytes (Saldanha-Araujo et.al. 2011). Moreover, our results points to a role of MSCs in the modulation of NF-kB signaling in activated T lymphocytes, switching from a canonical pro-inflammatory to a non-canonical immunoregulatory role (Saldanha-Araujo et.al. 2011b). We have also provided evidence for the role of non-canonical NF-kB signaling in the characteristic molecular features of HSC derived from Umbilical Cord Blood (UCB), as compared to Bone Marrow (BM). We are currently starting to address the molecular mechanisms by which MSC become activated to exert their immunomodulatory properties, upon treatment with pro-inflammatory stimuli (a mechanism generally referred as MSC “licensing” or “conditioning”). Finally, we are currently using synthetic pre-miRs and anti-miRs to explore the roles of microRNAs in the regulation of distinct stem cell characteristics (including pluripotency, differentiation, self-renewal, among others), and to identify functionally-relevant microRNA targets (trough coupled microarray profiling).
Lab Staff		Laboratory Coordinator Prof. Rodrigo A. Panepucci, PhD Researcher (FUNDHERP) Fellows Researchers Rodrigo Haddad, PhD Post-Doc/FAPESP Lucila Habib Bourguignon Oliveira PhD student/FAPESP Mariane Serra Fraguas PhD student/FAPESP Danuta Sastre PhD student/CAPES Ildercílio Mota de Souza Lima Ms student/CAPES Lara Martinelli Zapata Ms student/CAPES Bruno Braga Sangiorgi Ms student/CAPES Vitor Leão Ms student/CAPES Molecular Biology Technicians Amélia Góes Araujo (FMRP-USP) Marli Haydee Tavella (FUNDHERP) Josiane Lilian dos Santos Schiavinato, Ms. (FMRP-USP)
Collaborators		Vanderson Rocha, PhD, MD (Hosp. Sírio Libanês, SP). Hosp. Sírio Libanês, SP silviatoledo@graacc.org.br Felipe Saldanha Araujo, PhD (UNB, Brasília-DF). UNB, Brasília-DF. silviatoledo@graacc.org.br Francisco de Paula Careta, PhD (UFES, -ES). UFES, -ES. silviatoledo@graacc.org.br
International Collaborators		Jaques Elion Inserm, UMR 763, Hôpital Robert Debré, Université Paris Diderot, France. Eliane Gluckman Eurocord, EBMT, Hôpital St. Louis Hospital, France. Carlos Martinez-A Centro Nacional de Biotecnología – CSIC, Univ. Autónoma de Madrid, Espanha Stephen Spellman CIBMTR National Marrow Donor Program, Minneapolis.
Facilities Coordination		Agilent 48-slides auto-loader High-Density Microarray Scanner and Axon GenePix 4000B (Molecular Devices).
Selected Publications		1. Saldanha-Araujo F., Haddad R., Malmegrim de Farias K.C., Alves Souza A.D., Palma P.V., Araujo A.G., Orellana M.D., Voltarelli J.C., Covas D.T., Zago M.A., Panepucci RA Mesenchymal stem cells promote the sustained expression of CD69 on activated T-lymphocytes: roles of canonical and non-canonical NF-kappaB signaling. Journal of cellular and molecular medicine. 2011a Jul 21. 2. Saldanha-Araujo F., Ferreira F.I., Palma P.V., Araujo A.G., Queiroz R.H., Covas D.T., Zago M.A., Panepucci RA Mesenchymal stromal cells up-regulate CD39 and increase adenosine production to suppress activated T-lymphocytes. Stem cell research. 2011b Jul;7(1):66-74. 3. Picanco-Castro V., Russo-Carbolante E., Reis L.C., Fraga A.M., de Magalhaes D.A., Orellana M.D., Panepucci RA, Pereira L.V., Covas D.T. Pluripotent reprogramming of fibroblasts by lentiviral mediated insertion of SOX2, C-MYC, and TCL-1A. Stem cells and development. 2011 Jan;20(1):169-80. 4. De Molfetta G.A., Luciola Zanette D., Alexandre Panepucci R., Dos Santos A.R., da Silva W.A., Jr., Antonio Zago M. Role of NFKB2 on the early myeloid differentiation of CD34+ hematopoietic stem/progenitor cells. Differentiation; research in biological diversity. 2010 Nov-Dec;80(4-5):195-203. 5. Panepucci RA, Oliveira L.H., Zanette D.L., Viu Carrara Rde C., Araujo A.G., Orellana M.D., Bonini de Palma P.V., Menezes C.C., Covas D.T., Zago M.A. Increased levels of NOTCH1, NF-kappaB, and other interconnected transcription factors characterize primitive sets of hematopoietic stem cells. Stem cells and development. 2010 Mar;19(3):321-32. 6. Covas D.T., Panepucci RA, Fontes A.M., Silva W.A., Jr., Orellana M.D., Freitas M.C., Neder L., Santos A.R., Peres L.C., Jamur M.C., Zago M.A. Multipotent mesenchymal stromal cells obtained from diverse human tissues share functional properties and gene-expression profile with CD146+ perivascular cells and fibroblasts. Experimental hematology. 2008 May;36(5):642-54. 7. Proto-Siqueira R., Panepucci RA, Careta F.P., Lee A., Clear A., Morris K., Owen C., Rizzatti E.G., Silva W.A., Jr., Falcao R.P., Zago M.A., Gribben J.G. SAGE analysis demonstrates increased expression of TOSO contributing to Fas-mediated resistance in CLL. Blood. 2008 Jul 15;112(2):394-7. 8. Panepucci RA, Calado R.T., Rocha V., Proto-Siqueira R., Silva W.A., Jr., Zago M.A. Higher expression of transcription targets and components of the nuclear factor-kappaB pathway is a distinctive feature of umbilical cord blood CD34+ precursors. Stem Cells. 2007 Jan;25(1):189-96. 9. Proto-Siqueira R., Figueiredo-Pontes L.L., Panepucci RA, Garcia A.B., Rizzatti E.G., Nascimento F.M., Ishikawa H.C., Larson R.E., Falcao R.P., Simpson A.J., Gout I., Filonenko V., Rego E.M., Zago M.A. PRAME is a membrane and cytoplasmic protein aberrantly expressed in chronic lymphocytic leukemia and mantle cell lymphoma. Leukemia research. 2006 Nov;30(11):1333-9. 10. Rizzatti E.G., Falcao R.P., Panepucci RA, Proto-Siqueira R., Anselmo-Lima W.T., Okamoto O.K., Zago M.A. Gene expression profiling of mantle cell lymphoma cells reveals aberrant expression of genes from the PI3K-AKT, WNT and TGFbeta signalling pathways. British journal of haematology. 2005 Aug;130(4):516-26. 11. Panepucci RA, Siufi J.L., Silva W.A., Jr., Proto-Siquiera R., Neder L., Orellana M., Rocha V., Covas D.T., Zago M.A. Comparison of gene expression of umbilical cord vein and bone marrow-derived mesenchymal stem cells. Stem Cells. 2004;22(7):1263-78. 12. Silva W.A., Jr., Covas D.T., Panepucci RA, Proto-Siqueira R., Siufi J.L., Zanette D.L., Santos A.R., Zago M.A. The profile of gene expression of human marrow mesenchymal stem cells. Stem Cells. 2003;21(6):661-9.