Lewis Joel Greene
Full Professor of Cell and Molecular Biology (retired) FMRP/USP |
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Education | 1951-1955 B.A (magna cum laude), Amherst College, Amherst Massachusetts 1955-1962 Ph D, Rockefeller University, C.H.W. HIRS and G.E. Palade (Research advisors) 1990 Full Professor, University of São Paulo, Brazil |
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Research Interests | Structure and function of proteins Protein- protein interactions Proteomics as an entry to cell biology Molecular basis of cancer Molecular basis of sepsis |
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Research Overview | The recent focus of our group has been to understand the molecular mechanisms involved in the development of diseases and cancer . We are collaborating with biologists, clinicians and chemists using the methodologies of protein chemistry and molecular biology to identify biomarkers for diagnosis and prognosis and to understand the processes involved. | |
Lab Staff | José César Rosa, PhD – Laboratory Collaborator | |
Collaborators | Carolina Hassibe Thomé, Pos Doc Germano Aguiar Ferreira, Doctoral Student José César Rosa Andréia Machado Leopoldino Dimas Tadeu Covas Vitor Marcel Faça Eduardo Magalhães Rego Wilson Araújo da Silva Júnior Roger Chammas |
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International Collaborators | ||
Facilities Coordination | Mass Spectrometry and Protein Chemistry Lab | |
Selected Publications | 1. SOBRAL, L. M. ; SOUSA, L.O. ; COLETTA, R. D. ; CABRAL, H. ; GREENE, L. J. ; TAJARA, E.H. ; GUTKIND, J. S. ; CURTI, C. ; Leopoldino, A. M. . Stable SET knockdown in head and neck squamous cell carcinoma promotes cell invasion and the mesenchymal-like phenotype in vitro, as well as necrosis, cisplatin sensitivity and lymph node metastasis in xenograft tumor models. Molecular Cancer , v. 13, p. 32, 2014.
2. Thomé, C. H. ; DOS SANTOS, G. A. ; FERREIRA, G. A. ; SCHEUCHER, P. S. ; IZUMI, C. ; Leopoldino, A. M. ; SIMAO, A. M. ; CIANCAGLINI, P. ; DE OLIVEIRA, K. T. ; CHIN, A. ; HANASH, S. M. ; FALCAO, R. P. ; REGO, E. M. ; Greene, L. J. ; Faça, V. M. . Linker for Activation of T-cell Family Member2 (LAT2) a Lipid Raft Adaptor Protein for AKT Signaling, Is an Early Mediator of Alkylphospholipid Anti-leukemic Activity. Molecular & Cellular Proteomics , v. 11, p. 1898-1912, 2012. Citações: 3| 4 3. Fontes, A. M. ; Melo, F.U.F. ; Greene, L.J. ; Faça, V. M. ; Lin, Y. ; Gerson, S.L. ; Covas, D. T. . Production of human factor VIII-FL in 293T cells using the bicistronic MGMT(P140K)-retroviral vector. Genetics and Molecular Research , v. 11, p. 775-789, 2012. 4. Miranda, H. C. ; HERAI, R. H. ; Thomé, C. H. ; Gomes, G. G. ; PANEPUCCI, R. A. ; ORELLANA, M. D. ; Covas, D. T. ; Muotri, A. R. ; Greene, L.J. ; Faça, V. M. . A quantitative proteomic and transcriptomic comparison of human mesenchymal stem cells from bone marrow and umbilical cord vein. Proteomics (Weinheim. Print) , v. 12, p. 2607-2617, 2012. Citações: 3| 6 5. Spiller, F. ; FERREIRA, S. H. ; Greene, L. J. ; Rosa, J. C. ; Altruda, F. ; Souto, F. O. ; Hirsch, E. ; Mestriner, F. L. A. C. ; Cunha, F. Q. ; Tolosano, E. ; Alves-Filho, J. C. ; Laure, H. J. ; Freitas, A. ; Costa, C. ; Vinchi, F. . Inhibition of Neutrophil Migration by Hemopexin Leads to Increased Mortality Due to Sepsis in Mice. American Journal of Respiratory and Critical Care Medicine , v. 183, p. 922-931, 2011. Citações: 7| 7 6. Santos, G. A. S. ; Thomé, C. H. ; FERREIRA, G.A. ; YONEDA, J. S. ; NOBRE, T. M. ; Daghastnali, K.R.P. ; SCHEUCHER, P. S. ; TEIXEIRA, H. L. ; Constantino, M. G. ; DE OLIVEIRA, K. T. ; Faça, V. M. ; FALCAO, R. P. ; GREENE, L. J. ; REGO, E. M. ; CIANCAGLINI, P. . Interaction of 10-(octyloxy) decyl-2-(trimethylammonium) ethyl phosphate with mimetic membranes and cytotoxic effect on leukemic cells. Biochimica et Biophysica Acta. Biomembranes , v. 1798, p. 1714-1723, 2010. Citações: 4| 5 7. Mestriner, F. L. A. C. ; Spiller, F. ; Laure, H. J. ; Souto, F. O. ; TAVARES-MURTA, B.M. ; Rosa, J. C. ; Basile Filho, A. ; FERREIRA, S. H. ; GREENE, L. J. ; Cunha, F. Q. . Acute-phase protein α -1-acid glycoprotein mediates neutrophil migration failure in sepsis by a nitric oxide-dependent mechanism.. Proceedings of the National Academy of Sciences of the United States of America (Online) , v. 104, p. 19595-19600, 2007. Citações: 20| 22 8. SOUZA, G. A. ; GODOY, L.M.F. de ; TEIXEIRA, V. R. ; OTAKE, A. H. ; SABINO, A. ; Rosa, J. C. ; Dinarte, A. R. ; Pinheiro, D. G. ; Silva Jr, W. A. ; EBERLIN, M. N. ; Chammas, R. ;GREENE, L. J. . Proteomic and SAGE profiling of murine melanoma progression indicates the reduction of proteins responsible for ROS degradation. Proteomics, Inglaterra, v. 6, n.5, p. 1460-1470, 2006. Citações: 22| 22 |
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