GOALS

I. BASIC RESEARCH

1 – Establishment of human embryonic stem cell (hESCs) line for pre-clinical studies
2 – Differentiation of pluripotent stem cells into blood cells
3 – Generation and characterization of iPS from patients and normal individuals
4 – Determination of imprinting patterns during cell reprogramming
5 – Evaluation of the functional role of microRNAs associated with pluripotency and differentiation of pluripotent cells
6 – Evaluation of the ability of endothelial cells of several origins to transit into the mesenchymal phenotype in vitro through EndMT
7 – Study of the molecular mechanisms involved in the increased immunomodulatory properties of mesenchymal stromal cells (MSC) by inflammatory stimuli
8 – Evaluation of the biological differences in clonal cells between monoclonal B-cell lymphocytosis (MBL) and chronic lymphocytic leukemia (CLL)
9 – Genome wide analysis of cancer cells and cancer stem cells from different solid tumors
10 – Analysis of genetic and epigenetic changes in cancer/leukemia stem cells
11 – Phenotypic, molecular and functional analysis of mesenchymal stromal cells from healthy individuals and patients with viral infections and hematological diseases.

II. CLINICAL RESEARCH

12 – Clinical application of stem cells

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