1996-2001 Graduated in Chemical Engineering, State University of Maringá, Brazil
|Research Interests|| |
Recombinant Protein Production
|Research Overview|| |
Our group is focused on the development of bioprocess for recombinant protein production in bioreactors using human cell lines. The research team has succeeded in developing a process for bioreactor production and purification of recombinant factor VIII based on human hepatic cell line and lentiviral vector. In addition, we are also focused on the development of robust, scalable and cGMP-compliant process for large scale stem cell expansion. Specifically, we are expanding human mesenchymal stem cells on microcarriers and spinner flasks and also investigating bioreactor types for clinical-grade stem cell expansion.
|Lab Staff|| |
Mário Soares de Abreu Neto, Master Degree, Process Technician
Claudio Alberto Torres Suazo, PhD
Elisabeth de Fátima Pires Augusto, PhD
|International Collaborators|| |
Amine Kamen, PhD
|Facilities Coordination|| |
|Selected Publications|| |
1. Swiech, kamilla; Kamen, Amine; Ansorge, Sven; Durocher, Yves; Picanço-Castro, Virgínia; Russo-Carbolante, Elisa ; Neto, Mário S.A.; Covas, Dimas Tadeu. Transient Transfection of Serum-Free Suspension HEK 293 Cell Culture for Efficient Production of Human rFVIII. BMC Biotechnology, 2011: 11, 114.