Júlio César Voltarelli – Center for Cell-based Therapy

		Júlio César Voltarelli Full Professor of Clinical Medicine, Division of Clinical Immunology, Medical School of Ribeirão Preto, University of São Paulo, Brazil. In memorian jcvoltar@fmrp.usp.br PubMed Scopus Scielo ResearchID
Education		1967-1972 Graduated in Medicine, Medical School of Ribeirão Preto, University of São Paulo, Brazil 1973-1974 Residence in Clinical Medicine and Hematology, Medical School of Ribeirão Preto, University of São Paulo, Brazil 1975-1978 Masters in Clinical Medicine, Medical School of Ribeirão Preto, University of São Paulo, Brazil 1978-1981 PhD in Clinical Medicine, Medical School of Ribeirão Preto, University of São Paulo, Brazil of Ribeirão Preto, University of São Paulo, Brazil 1985-1986 Postdoctoral Research Fellow, University of California, San Francisco, USA 1987-1988 Postdoctoral Research Fellow, Fred Hutchinson Cancer Research Center, Seattle, USA 1989 Full Professor, University of São Paulo, Brazil 1999-2000 Postdoctoral Research Fellow, Scripps Research Institute, San Diego, California, USA
Research Interests		Bone Marrow Transplantation Autoimmune Diseases Cell therapy Immunogenetics Applied Immunology
Research Overview		The major goal of our group is to evaluate the therapeutic potential of stem cell transplantation in patients with autoimmune diseases and to understand the immune mechanisms involved in those therapies. The group has experience with basic and applied immunology, experimental animal models of autoimmune diseases, transplantation and cell therapy. The research lines include: a, Treatment of autoimmune diseases with autologous hematopoietic stem cell transplantation: evaluation of therapeutic response and mechanisms of action; Treatment of experimental models of autoimmune diseases with mesenchymal stem cell infusions: evaluation of therapeutic response and mechanisms of action; Treatment of extensive burn wounds with mesenchymal stem cells: evaluation of therapeutic response and mechanisms of action; Analysis of functional characteristics and genetic profiling of stem cells isolated from patients with autoimmune diseases.
Lab Staff		Bone Marrow Transplantation Group Belinda P. Simoes Medical Doctor, PhD Maria C. B. Oliveira Medical Doctor, PhD Ana B. P. L. Stracieri Medical Doctor, PhD Daniela A. Moraes Medical Doctor, PhD Fabiano Pieroni Medical Doctor, PhD George M. N. Barros Medical Doctor, PhD Carlos E. B. Couri Medical Doctor, PhD Basic and Applied Immunology Group Kelen Cristina Ribeiro Malmegrim Researcher, PhD Carolina Caliári Oliveira, PhD Student Mariana Rodrigues Davanso, Master Student Júlia Teixeira Cottas de Azevedo, Master Student Kalil Alves de Lima, Master Student Lucas Coelho Marliére Arruda, PhD Student Rosane Falasco Bolzoni, Technician Ana Júlia Bandeira Machry, Technician
Collaborators		Eduardo Donadi, MD, PhD Faculdade de Medicina de Ribeirão Preto, USP Departamento de Clínica Médica Laboratório de Imunogenética eadonadi@fmrp.usp.br João Santana da Silva, PhD Faculdade de Medicina de Ribeirão Preto, USP Departamento de Bioquímica e Imunologia Laboratório de Imunoparasitologia jsdsilva@fmrp.usp.br Milton César Foss, PhD Faculdade de Medicina de Ribeirão Preto, USP Departamento de Clínica Médica Laboratório de Endocrinologia mcfoss@fmrp.usp.br Ângela Leal, MD, PhD Universidade Federal de São Carlos Departamento de Medicina Laboratório de Endocrinologia angelaleal@ufscar.br
International Collaborators		Richard K. Burt, MD, PhD Associate Professor in Medicine-Immunotherapy for Autoimmune Diseases Northwestern University Feinberg School of Medicine Division of Immunotherapy Chicago, IL 60611, USA rburt@northwestern.edu Dominique Farge, MD, PhD Professor of Internal Medicine Unité de Médecine Interne et Pathologie Vasculaire Inserm U976, Hopital Saint-Louis, AP-HP, Paris-7 Université Denis Diderot 1 avenue Claude Vellefaux, 75010 Paris Dominique.farge-bancel@sls.aphp.fr Bart Otto Roep, MD, PhD Professor of Medicine (Diabetology & Immunopathology) Leiden University Medical Center Department Immunohematology & Blood Transfusion, E3-Q Albinusdreef 2 2333 ZA Leiden, The Netherlands B.O.Roep@lumc.nl
Facilities Coordination		HLA Genotyping Laboratory (Blood Center of Ribeirão Preto, School of Medicine of Ribeirão Preto, University of São Paulo, Brazil) Bone Marrow Transplantation Unit (University Hospital, School of Medicine of Ribeirão Preto, University of São Paulo, Brazil)
Selected Publications		1. Couri CE, Voltarelli JC.Stem cell-based therapies and immunomodulatory approaches in newly diagnosed type 1 diabetes. Curr Stem Cell Res Ther. 2011 Mar 1; 6(1):10-5. 2. Godoi DF, Cardoso CR, Ferraz DB, Provinciatto PR, Cunha FQ, Silva JS, Voltarelli JC. Hematopoietic SCT modulates gut inflammation in experimental inflammatory bowel disease. Bone Marrow Transplant. 2010 Oct; 45(10):1562-71. 3. Couri CE, Oliveira MC, Stracieri AB, Moraes DA, Pieroni F, Barros GM, Madeira MI, Malmegrim KC, Foss-Freitas MC, Simões BP, Martinez EZ, Foss MC, Burt RK, Voltarelli JC. C-peptide levels and insulin independence following autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus. JAMA. 2009, 301(15):1573-9. 4. Autologous non-myeloablative haemopoietic stem cell transplantation in relapsing-remitting multiple sclerosis: a phase I/II study. Burt RK, Loh Y, Cohen B, Stefoski D, Balabanov R, Katsamakis G, Oyama Y, Russell EJ, Stern J, Muraro P, Rose J, Testori A, Bucha J, Jovanovic B, Milanetti F, Storek J, Voltarelli JC, Burns WH. Lancet Neurol. 2009 Mar; 8(3):244-53. 5. Voltarelli JC, Couri CE, Stracieri AB, Oliveira MC, Moraes DA, Pieroni F, Barros GM, Madeira MI, Malmegrim KC, Foss-Freitas MC, Simões BP, Foss MC, Squiers E, Burt RK. Autologous hematopoietic stem cell transplantation for type 1 diabetes. Ann. N. Y. Acad Sci. 2008 Dec; 1150:220-9. 6. Voltarelli JC, Couri CEB, Oliveira MCB, Stracieri ABPL, Moraes DA, Godoi DF, Coutinho MA, Malmegrim KCR, Foss-Freitas MC, Foss MC, Simões BP, Squiers EC, Burt RK.Autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus. JAMA. 2007; 297:1568-1576. 7. Pieroni F, Stracieri AB, Moraes DA, Paton EJ, Saggioro FP, Barros GM, Barros JC, Oliveira MC, Coutinho MA, Castro NS, Vigoritto AC, Trabasso P, Souza CA, de Souza MP, Mauad MA, Colturato VA, Simões BP, Foss NP, Voltarelli JC. Six cases of leprosy associated with allogeneic hematopoietic SCT. Bone Marrow Transplant. 2007; 40(9):859-63. 8. Burt RK, Marmont A, Oyama Y, Slavin S, Arnold R, Hiepe F, Fassas A, Snowden J, Schuening F, Myint H, Patel DD, Collier D, Heslop H, Krance R, Statkute L, Verda L, Traynor A, Kozak T, Hintzen RQ, Rose JW, Voltarelli J, Loh Y, Territo M, Cohen BA, Craig RM, Varga J, Barr WG. Randomized controlled trials of autologous hematopoietic stem cell transplantation for autoimmune diseases: the evolution from myeloablative to lymphoablative transplant regimens. Arthritis Rheum. 2006; 54(12):3750-60. 9. Couri CEB, Foss MC, Voltarelli JC. Secondary prevention of type I diabetes mellitus: stopping immune destruction and promoting B-cell regeneration. Braz J Med Biol Res. 2006; 39:1271-1280. 10. Burt RK, Cohen B, Rose J, Petersen F, Oyama Y, Stefoski D, Katsamakis G, Carrier E, Kozak T, Muraro PM, Martin R, Hintzen R, Slavin S, Karussis D, Haggiag S, Voltarelli JC, Ellison GW, Jovanovic B, Popat U, McGuirk J, Statkute L, Verda L, Haas J, Arnold R. Hematopoietic stem cell transplantation for multiple sclerosis. Arch Neurol 2005; 62: 860-864. 11. Voltarelli JC, Oliveira MCB, Stracieri ABPL, Godoi DF, Moraes DA, Coutinho MA, Malmegrim KCR, Santos AC. Hematopoietic stem cell transplantation for refractory Takayasu’s arteritis. Rheumatology 2004; 43:1308-1309. 12. Voltarelli JC, Ouyang J. Hematopoietic stem cell transplantation for autoimmune diseases in developing countries: current status and future prospectives. Bone Marrow Transplant. 2003; 32: S69-S71.