Elisa Maria de Sousa Russo Carbolante
1988-1991 Graduated in Pharmacy, University of São Paulo, Brazil
|Research Overview||Our group has two main focuses which are the expression of recombinant proteins and the reprogramming of cells. The proteins are expressed in our laboratory to be used as therapeutic drugs (FVIII and FIX), in diagnostic tests (HIV and HTLV) and also to reprogram cells (oct4, sox2, KLF4). We have reprogrammed fibroblasts to iPS cells using the genetic modification approach employing a combination of transcription factors, delivered by lentivirus, different from the classic one (OSKM). Now we are interested in reprogram the cells without the genetic modification and for this purpose we are going to use the direct modification of cells (from fibroblasts to hematopoietic cells) and also we are expressing the transcription factors involved in the manutence of pluripotency to reprogram the cells using these proteins.|
Recombinant, Protein Group
Cell Modification Group
Angelo A Cardoso, PhD
Lygia Veiga Pereira
1. BRESSAN, F.F. ; Miranda, M ; Perecin, F ; BEM, T. H. C. ; PEREIRA, F. T. V. ; RUSSO-CARBOLANTE, EMS ; Alves, DCC ; Strauss, B ; Bajgelma, M ; Krieger, JE ; Binelli, M ; Meirelles FV . Improved production of genetically modified fetuses with homogeneous transgene expression after transgene integration site analyses and recloning in catle. Cellular Reprogramming, v. 13, p. 29-36, 2011.