Felipe Perecin


Felipe Perecin
Assistant Professor, FZEA/USP
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1998-2002 Graduated in Veterinary Medicine, FCAV-UNESP, Brazil
2003-2007 PhD in Animal Reproduction/Veterinary Medicine, FCAV-UNESP, Brazil
2007-2008 Postdoctoral Research Fellow, FZEA, University of São Paulo 

Research Interests  

Nuclear Reprogramming
Nuclear Transfer
Imprinted genes 

Research Overview   The major focus of our group is to understand cellular and molecular mechanisms involved in nuclear reprogramming and in the epigenetic control for imprinted genes. We investigate the epigenetic mechanisms controlling genomic imprinting exposing cell lines to chromatin-modifying agents or exposing early embryos to different in vitro conditions and correlating the allele-specific epigenetic modifications with allele-specific expression. 
Lab Staff  

Mariane Ferracin Martucci PhD Student
Mariana Fonseca MSc Student
Monalisa Bomfim Undergrad Student
Marina Amaro Lima Undergrad Student


Flávio Vieira Meirelles, PhD
Laboratório de Morfofisiologia Molecular e Desenvolvimento
FZEA – Universidade de São Paulo

International Collaborators  

Lawrence C. Smith, PhD
Centre de Recherche en Reproduction Animale
Faculté de Médecine Vétérinaire
Université de Montrea – Canadal

Facilities Coordination    
Selected Publications  

1. Sangalli JR; De Bem THC; Perecin F; Chiaratti MR; Oliveira LJ; Araújo RR; Pimentel JRV; Smith LC; Meirelles FV. Treatment of nuclear-donor cells or cloned zygotes with chromatin-modifying agents increases histone acetylation but does not improve full-term development of cloned cattle. Cellular Reprogramming (formely “Cloning and Stem Cells”), NO PRELO, 2012. (DOI: 10.1089/cell.2011.0079).
2. De Bem THC; Chiaratti MR; Rochetti R; Bressan FF; Sangalli JR; Miranda MS; Pires PRL; Schwartz KRL; Sampaio RV; Fantinato Neto P; Pimentel JRV; Perecin F; Smith LC; Meirelles FV; Adona PR; Leal CLV. Viable calves produced by somatic cell nuclear transfer using pre-matured oocytes. Cellular Reprogramming (formely “Cloning and Stem Cells”), v.13, n.5, p.419-429, 2011. (DOI: 10.1089/cell.2011.0010).
3. Barreto RSN; Bressan FF; Oliveira LJ; Pereira FTV; Perecin F; Ambrósio CE; Meirelles FV; Miglino MA. Gene expression in placentation of farm animals: an overview of gene function during development. Theriogenology. v.76, n.4, p.589-597, 2011. (DOI: 10.1016/j.theriogenology.2011.03.001).
4. Suzuki J; Therrien J; Filion F; Lefebvre R; Goff AK; Perecin F; Meirelles FV; Smith LC. Loss of methylation at H19 DMR is associated with biallelic expression and reduced development in somatic cell nuclear transfer cattle. Biology of Reproduction, v.84, p.947-956, 2011. (DOI: 10.1095/biolreprod.110.087833).
5. Chiaratti MR; Ferreira CR; Perecin F; Meo SC; Sangalli JR; Mesquita LG; Balieiro JCC; Smith LC; Garcia JM; Meirelles FV. Ooplast-mediated developmental rescue of bovine oocytes exposed to ethidium bromide. Reproductive Biomedicine Online, v.22; n.2; p.172-183, 2011. (DOI: 10.1016/j.rbmo.2010.10.011).
6. Bressan FF; Miranda MS; Perecin F; De Bem THC; Pereira FTV; Russo-Carbolante EM; Alves D; Strauss B; Bajgelman M; Krieger JE; Binelli M; Meirelles FV. Improved production of genetically modified fetuses with homogeneous transgene expression after transgene integration site analysis and recloning in cattle. Cellular Reprogramming (formerly “Cloning and Stem Cells”), v.13; n.1; p.29-36, 2011. (DOI: 10.1089/cell.2010.0022).
7. Ferreira CR; Burgstaller JP; Perecin F; Garcia JM; Chiaratti MR; Meo SC; Müller M; Smith LC; Meirelles FV; Steinborn R. Pronounced segregation of donor mitochondria introduced by bovine ooplasmic transfer to the female germ-line. Biology of Reproduction, v.82, n.3, p.563-571, 2010. (DOI: 10.1095/biolreprod.109.080564)..
8. Chiaratti MR; Ferreira CR; Meirelles FV Meirelles; Meo SC; Perecin F; Smith LC; Ferraz ML; Sá Filho MF; Gimenes LU; Baruselli PS; Gasparrini B; Garcia JM. Xenooplasmic transfer between buffalo and bovine enables development of homoplasmic offspring. Cellular Reprogramming (formerly “Cloning and Stem Cells”), v.12, n.3, p.231-236, 2010. (DOI: 10.1089/cell.2009.0076).
9. Bressan FF; De Bem THC; Perecin F; Lopes FL; Ambrosio CE; Meirelles FV; Miglino MA. Unearthing the roles of imprinted genes in the placenta. Placenta (Eastbourne), v.30, p.823-834, 2009. (DOI: 10.1016/j.placenta.2009.07.007).
10. Miranda MS; Bressan FF; Zecchin KG; Vercesi AE; Mesquita LG; Merighe GKF; King WA; Ohashi OM; Pimentel JRV; Perecin F; Meirelles FV. Serum-Starved Apoptotic Fibroblasts Reduce Blastocyst Production but Enable Development to Term after SCNT in Cattle. Cloning and Stem Cells, v.11, n.4, p.565-573, 2009. (DOI: 10.1089/clo.2009.0028).
11. Perecin F; Meo SC; Yamazaki W; Ferreira CR; Merighe GKF; Meirelles FV; Garcia JM. Imprinted gene expression in in vivo- and in vitro-produced bovine embryos and chorio-allantoic membranes. Genetics and Molecular Research, v.8, p.76-85, 2009. (DOI: 10.4238/vol8-1gmr541).
12. Saraiva NZ; Perecin F; Meo SC; Ferreira CR; Tetzner TAD; Garcia JM. Demecolcine effects on microtubule kinetics and on chemically assisted enucleation of bovine oocytes. Cloning and Stem Cells, v.11, p.141-152, 2009. (DOI: 10.1089/clo.2008.0044).
13. Meo SC; Ferreira CR; Perecin F; Saraiva NZ; Tetzner TAD; Yamazaki W; Leal CLV; Meirelles FV; Garcia JM. Karyoplast exchange between strontium- and 6-DMAP-parthenogenetically activated zygotes of cattle. Animal Reproduction Science (Print), v.116, p.381-385, 2009. (DOI: 10.1016/j.anireprosci.2009.02.020).
14. Meo SC; Yamazaki W; Ferreira CR; Perecin F; Saraiva NZ; Leal CLV; Garcia JM. Parthenogenetic activation of bovine oocytes using single and combined strontium, ionomycin and 6-dimethylaminopurine treatments. Zygote (Cambridge), v.15, p.295-306, 2007. (DOI: 10.1017/s0967199407004285).
15. Ferreira CR; Meirelles FV; Yamazaki W; Chiaratti MR; Meo SC; Perecin F; Smith LC; Garcia JM. The kinetics of donor cell mtDNA in embryonic and somatic donor cell-derived bovine embryos. Cloning and Stem Cells, v.9, p.618-629, 2007. (DOI: 10.1089/clo.2006.0082). 

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