Virgínia Picanço e Castro
1995-1999 Graduated in Biologic Sciences, University of São Paulo (FFCLRP-USP), Brazil
Pluripotent Stem Cells
|Research Overview||The major focus of our group is to understand the pluripotent pathway involved in cell reprogramming process. The goal of our laboratory is to generate pluripotent stem cells from human somatic cells. In addition, our group is interested in the characterization of molecular pathways and genomic targets that regulate hematopoietic and pluripotent stem cells differentiation. Our group aims to create a database of genomic proto-proteins involved in hematopoietic differentiation. The identification of new biomolecules will enable the overexpression of genes involved in differentiation pathway resulting in an in vitro differentiation protocol more effective, and also a new set of genes might be use in direct reprogramming of fibroblasts into adult blood cells. This project may bring as benefits to Brazilian society the possibility of obtaining cells more efficient and secure, as well as the formation of human resources with interdisciplinary character capable of dealing with this type of technology that is still little explored in our country.|
Biotecnology Laboratory Group
Flávio Vieira Meirelles, PhD
Lygia da Veiga Pereira, PhD
Angelo Manuel de Almeida Cardoso, M.D., Ph.D.
1. Sousa Russo-Carbolante, Elisa Maria ; Picanço-Castro, Virgínia ; Alves, Daiani Cristina Cilão ; Fernandes, Andrielle Castilho ; Almeida-Porada, Graça ; TONN, Torsten ; COVAS, Dimas Tadeu . Integration pattern of HIV-1 based lentiviral vector carrying recombinant coagulation factor VIII in Sk-Hep and 293T cells. Biotechnology Letters, v. 33, p. 23-31, 2011.